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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 No.1/2, Feb-Apr 2003
ORIGINAL ARTICLE
Steroid
modulation of angiotensin II action in the rat anterior pituitary
gland
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2003;
24:91–95
pii: NEL241203A15
PMID: 12743541
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Steroid
modulation of angiotensin II action in the rat anterior pituitary
gland
Agnieszka
Lachowicz 1, Tomasz Ochedalski 2 & Elzbieta
Rebas 3
1.
Department of Experimental Endocrinology and Hormone Research,
Institute of Endocrinology,
2. Institute of Gynecology and Obstetrics,
3. Department of Biochemistry, Institute of Physiology and
Biochemistry, Medical University of Lodz, POLAND.
Submitted:
June 12, 2002 Accepted: October 26, 2002
Key
words:
angiotensin II, inositol-1,4,5-trisphosphate, pituitary,
pregnenolone sulfate, 17b-estradiol,
progesterone, dehydroepiandrosterone sulfate
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Abstract
OBJECTIVES:
The present study was designed to test whether various steroid
hormones modulate differently angiotensin II (AngII) action
in the anterior pituitary in males and females.
MATERIAL
AND METHODS: Adult female and male rats were treated with
one of the following substances: oil (control), pregnenolone
sulfate (PREG-S), 17b-estradiol
benzoate (E2,) progesterone (P), or dehydroepiandrosterone
sulfate (DHEA-S), given in intraperitoneal injections for
five days in dose of 50 µg per animal per day. Because
AngII is known to act in the anterior pituitary through the
phosphatidiloinositol breakdown, thus increasing the level
of inositol-1,4,5-trisphosphate (IP3), the IP3 concentration
was determined 24 hours after the injection in the anterior
pituitary homogenate exposed to AngII.
RESULTS:
In control animals (without steroids) AngII stimulated concentration
of IP3 stronger in females than in males. E2 and DHEA-S enhanced
AngII effects in both males and females. PREG-S increased
AngII-induced IP3 concentration in females, but not males.
Progesterone raised AngII effect on IP3 concentration in males,
only when high concentrations of peptide were used.
CONCLUSION: These results indicate that pituitary sensitivity
to AngII stimulation is modulated by steroid hormones and
is related to the gender of the animal.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
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