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NEL Vol.24 No.1/2, Feb-Apr 2003


Steroid modulation of angiotensin II action in the rat anterior pituitary gland

2003; 24:9195
pii: NEL241203A15
PMID: 12743541

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Steroid modulation of angiotensin II action in the rat anterior pituitary gland

Agnieszka Lachowicz 1, Tomasz Ochedalski 2 & Elzbieta Rebas 3

1. Department of Experimental Endocrinology and Hormone Research, Institute of Endocrinology,
2. Institute of Gynecology and Obstetrics,
3. Department of Biochemistry, Institute of Physiology and Biochemistry, Medical University of Lodz, POLAND.

Submitted: June 12, 2002 Accepted: October 26, 2002

Key words:
angiotensin II, inositol-1,4,5-trisphosphate, pituitary, pregnenolone sulfate, 17b-estradiol, progesterone, dehydroepiandrosterone sulfate



OBJECTIVES: The present study was designed to test whether various steroid hormones modulate differently angiotensin II (AngII) action in the anterior pituitary in males and females.

MATERIAL AND METHODS: Adult female and male rats were treated with one of the following substances: oil (control), pregnenolone sulfate (PREG-S), 17b-estradiol benzoate (E2,) progesterone (P), or dehydroepiandrosterone sulfate (DHEA-S), given in intraperitoneal injections for five days in dose of 50 µg per animal per day. Because AngII is known to act in the anterior pituitary through the phosphatidiloinositol breakdown, thus increasing the level of inositol-1,4,5-trisphosphate (IP3), the IP3 concentration was determined 24 hours after the injection in the anterior pituitary homogenate exposed to AngII.

RESULTS: In control animals (without steroids) AngII stimulated concentration of IP3 stronger in females than in males. E2 and DHEA-S enhanced AngII effects in both males and females. PREG-S increased AngII-induced IP3 concentration in females, but not males. Progesterone raised AngII effect on IP3 concentration in males, only when high concentrations of peptide were used.
CONCLUSION: These results indicate that pituitary sensitivity to AngII stimulation is modulated by steroid hormones and is related to the gender of the animal.

Copyright  Neuroendocrinology Letters 2003
Society of Integrated Sciences
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