Articles by author - Marie Stiborova

Modulation of cytochrome P450 enzyme system by selected flavonoids.

Hodek P, Tepla M, Krizkova J, Sulc M, Stiborova M.

Journal Article 2009; 30(Suppl 1): 67-71 PubMed PMID: 20027147  Keywords:  Animals, Antioxidants:pharmacology, Benzoflavones:chemistry, Carbon Monoxide:metabolism, Cytochrome P-450 Enzyme System:metabolism, Cytochromes b5:metabolism, Cytochromes c:metabolism, Ferricyanides:metabolism, Flavonoids:chemistry, Fluorometry, Male, Mic.    Citation

OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activ.....

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Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.

Martinkova E, Dontenwill M, Frei E, Stiborova M.

Journal Article 2009; 30(Suppl 1): 60-66 PubMed PMID: 20027146  Keywords:  Antineoplastic Agents:administration & dosage, Autoradiography, Blotting, Western, Cell Line, Tumor, Cell Proliferation:drug effects, Cell Survival:drug effects, Chromatography, High Pressure Liquid, Cytochrome P-450 Enzyme System:metabolism, DNA Adducts:.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action with promising brain tumor specificity. .....

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Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes.

Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M.

Journal Article 2009; 30(Suppl 1): 52-59 PubMed PMID: 20027145  Keywords:  Animals, Benz(a)Anthracenes:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Male, Microsomes, Liver:enzymology, Oxidati.    Citation

OBJECTIVES: 3-Aminobenzanthrone (3-ABA) is the main human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone (3-NBA). .....

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Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole.

Svobodova M, Martinkova M, Dracinska H, Frei E, Stiborova M.

Journal Article 2009; 30(Suppl 1): 46-51 PubMed PMID: 20027144  Keywords:  Animals, Anisoles:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Microsomes, Liver:enzymology, Nitrophenols:metabolism.    Citation

OBJECTIVES: 2-Nitrophenol (2-NP) is the major detoxification metabolite of an important industrial pollutant and a potent carcinogen, 2-ni.....

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A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase.

Semanska M, Dracinsky M, Martinek V, Hudecek J, Hodek P, Frei E, Stiborova M.

Journal Article 2008; 29(5): 712-716 PubMed PMID: 18987613  Keywords:  Carcinogens:chemistry, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Electrons, Horseradish Peroxidase:chemistry, Hydrogen Peroxide:chemistry, Magnetic Resonance Spectroscopy, Mass Spectrometry, Naphthols:chemistry, Oxidation-Reduction.    Citation

OBJECTIVES: The aim of the study was to examine oxidation of carcinogenic Sudan I by peroxidase and characterize the structure of its two .....

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Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

Sistkova J, Hudecek J, Hodek P, Frei E, Schmeiser H, Stiborova M.

Journal Article 2008; 29(5): 733-737 PubMed PMID: 18987598  Keywords:  Animals, Aristolochic Acids:pharmacokinetics, Carcinogens:pharmacokinetics, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1:isolation & purification, Cytochrome P-450 CYP1A2:isolation & purification, Humans, Inactivation, Metabolic, Mice, Mi.    Citation

OBJECTIVES: A carcinogenic and nephrotoxic plant alkaloid, aristolochic acid (AA), causes the development of aristolochic acid nephropathy.....

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