Articles by author - Jan Smidrkal

Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.

Drabikova K, Perecko T, Nosal R, Rackova L, Ambrozova G, Lojek A, Smidrkal J, Harmatha J, Jancinova V.

Journal Article 2010; 31(Suppl 2): 73-78 PubMed PMID: 21187835  Keywords:  Adult, Animals, Cell Line, Coumarins:pharmacology, Humans, Lipopolysaccharides:pharmacology, Macrophages:cytology, Male, Mice, Middle Aged, Models, Animal, Neutrophils:cytology, Nitric Oxide:metabolism, Phagocytosis:drug effects, Reactive Oxygen Species:m.    Citation

OBJECTIVE: Activated phagocytes, generating a variety of powerful inflammatory mediators, such as oxygen and nitrogen species, may partici.....

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Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.

Perecko T, Drabikova K, Rackova L, Ciz M, Podborska M, Lojek A, Harmatha J, Smidrkal J, Nosal R, Jancinova V.

Journal Article 2010; 31(Suppl 2): 84-90 PubMed PMID: 21187824  Keywords:  Antioxidants:pharmacology, Apoptosis:drug effects, Caspase 3:metabolism, Cell Survival:drug effects, Computer Simulation, Dose-Response Relationship, Drug, Humans, In Vitro Techniques, Male, Neutrophils:cytology, Phosphorylation:drug effects, Protein Kina.    Citation

OBJECTIVE: Pterostilbene, a naturally occurring phenolic derivative, exhibits various pharmacological effects, e.g. anti-cancerous, antiox.....

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