Articles by author - Jan Smetana

Caco-2 cells and Biopharmaceutics Classification System (BCS) for prediction of transepithelial transport of xenobiotics (model drug: caffeine).

Smetanova L, Stetinova V, Kholova D, Kvetina J, Smetana J, Svoboda Z.

Journal Article 2009; 30(Suppl 1): 101-105 PubMed PMID: 20027153  Keywords:  Biological Transport:drug effects, Caco-2 Cells, Caffeine:pharmacokinetics, Cell Culture Techniques, Cell Survival:drug effects, Diffusion, Humans, Hydrogen-Ion Concentration, Intestinal Absorption, Intestinal Mucosa:metabolism, Kinetics, Linear Models, M.    Citation

OBJECTIVES: The Caco-2 cell monolayer model is widely used as a standard screening tool for studying the mechanisms of cellular drug trans.....

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