Groh T, Hrabeta J, Poljakova J, Eckschlager T, Stiborova M.
Journal Article 2012; 33(Suppl 3): 16-24 PubMed PMID: 23353839 Keywords: Antineoplastic Agents, Phytogenic:pharmacology, Apoptosis:drug effects, Bone Marrow Neoplasms:drug therapy, Brain Neoplasms:drug therapy, Cell Cycle:drug effects, Cell Line, Tumor, Drug Resistance, Neoplasm:drug effects, Drug Synergism, Etoposide:pharmaco. CitationOBJECTIVES: Etoposide (Vepesid, VP-16), an inhibitor of topoisomerase II, is a chemotherapeutic drug commonly used for treatment of differ.....
Groh T, Hrabeta J, Poljakova J, Eckschlager T, Stiborova M. Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 16-24
Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M.
Journal Article 2011; 32(Suppl 1): 101-116 PubMed PMID: 22167207 Keywords: Animals, Antineoplastic Combined Chemotherapy Protocols:pharmacology, Brain Neoplasms:drug therapy, DNA Damage, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Ellipticines:administration & dosage, Histone Deacetylase Inhibitors:administra. CitationOBJECTIVES: Valproic acid (VPA) and trichostatin A (TSA) exert antitumor activity as histone deacetylase inhibitors, whereas ellipticine a.....
Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M. Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 101-116
Vilimkova L, Jechova J, Koubkova Z, Paca J, Kremlackova V, Poljakova J, Paca J, Stiborova M.
Journal Article 2009; 30(Suppl 1): 80-87 PubMed PMID: 20027149 Keywords: Candida tropicalis:enzymology, Catechol 1,2-Dioxygenase:chemistry, Catechols:chemistry, Chromatography, Chromatography, Gel, Chromatography, High Pressure Liquid, Cytosol:chemistry, Dextrans, Dimerization, Electrophoresis, Polyacrylamide Gel, Fungal Prote. CitationOBJECTIVES: Candida tropicalis yeast is a microorganism that possesses high tolerance for phenol and shows strong phenol degrading activit.....
Vilimkova L, Jechova J, Koubkova Z, Paca J, Kremlackova V, Poljakova J, Paca J, Stiborova M. Isolation and partial characterization of catechol 1,2-dioxygenase of phenol degrading yeast Candida tropicalis. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 80-87
Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M.
Evaluation Studies 2006; 27(Suppl 2): 18-22 PubMed PMID: 17159771 Keywords: Animals, Antineoplastic Agents:pharmacokinetics, Cytochrome P-450 Enzyme System:chemistry, DNA Adducts:metabolism, Ellipticines:pharmacokinetics, Metabolic Detoxication, Phase I, Microsomes, Liver:chemistry, Models, Biological, NADP:chemistry, NADPH-Ferri. CitationOBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple action mechanisms. Recently, we found that after cytochrome P.....
Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M. Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes. Neuro Endocrinol Lett. 2006 Dec; 27(Suppl 2): 18-22