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Articles by author - Kristina Melkersson

Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.

Melkersson K, Lewitt M, Hall K.

Comparative Study 2015; 36(5): 465-480 PubMed PMID: 26707048  Keywords:  Adult, Amino Acids:blood, Antipsychotic Agents:therapeutic use, Chromatography, Ion Exchange, Clopenthixol:therapeutic use, Clozapine:therapeutic use, Cohort Studies, Female, Glutamic Acid:blood, Haloperidol:therapeutic use, Humans, Insulin Resistance, Ma.    Citation

RATIONALE: The effect of long-term treatment with the atypical antipsychotic clozapine on the serum amino acid profile in schizophrenia pa.....

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Case report of a patient with schizophrenia and a mutation in the insulin receptor substrate-4 gene.

Melkersson K.

Case Reports 2013; 34(3): 173-176 PubMed PMID: 23685414  Keywords:  Amino Acid Substitution:genetics, Chromosomes, Human, X, Female, Humans, Insulin Receptor Substrate Proteins:genetics, Middle Aged, Schizophrenia, Paranoid:genetics, Signal Transduction:genetics,.    Citation

: This report deals with a female patient with schizophrenia who was found to have a mutation in the insulin receptor substrate-4 gene tha.....

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Metabolic parameters and long-term antipsychotic treatment: a comparison between patients treated with clozapine or olanzapine.

Feng S, Melkersson K.

Clinical Trial 2012; 33(5): 493-498 PubMed PMID: 23090266  Keywords:  Adult, Antipsychotic Agents:administration & dosage, Benzodiazepines:administration & dosage, Body Mass Index, Clozapine:administration & dosage, Diabetes Mellitus, Type 2:chemically induced, Female, Humans, Hyperglycemia:chemically induced, Hyperlipidemi.    Citation

OBJECTIVES: This study was undertaken to examine if patients exhibit more pronounced metabolic abnormalities after 8-year treatment with c.....

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Evidence for a negative association between schizophrenia and a polymorphism in the insulin receptor substrate-3 (IRS-3) gene.

Melkersson K, Persson B.

Journal Article 2012; 33(3): 321-330 PubMed PMID: 22635093  Keywords:  Adult, Case-Control Studies, Databases, Genetic, Female, Genetic Predisposition to Disease:genetics, Genotype, Humans, Insulin Receptor Substrate Proteins:genetics, Male, Middle Aged, Polymorphism, Single Nucleotide:genetics, Schizophrenia:genetics,.    Citation

OBJECTIVES: Since there are clear indications that schizophrenia is a systemic disorder, we sought for a common molecular basis for schizo.....

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Association between body mass index and insulin receptor substrate-4 (IRS-4) gene polymorphisms in patients with schizophrenia.

Melkersson K, Persson B.

Journal Article 2011; 32(5): 634-640 PubMed PMID: 22167131  Keywords:  Adult, Body Mass Index, Female, Genetic Predisposition to Disease:epidemiology, Genetic Variation:genetics, Genotype, Humans, Insulin Receptor Substrate Proteins:genetics, Male, Middle Aged, Obesity:epidemiology, Polymorphism, Single Nucleotide, Schizophr.    Citation

OBJECTIVES: The insulin receptor substrate-4 (IRS-4) protein is highly expressed in the hypothalamus that plays a main role in the regulat.....

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Effect of antipsychotic-induced hyperprolactinemia on anthropometric measures, insulin sensitivity and lipid profile in patients with schizophrenia or related psychoses.

Melkersson K, Berinder K, Hulting A.

Comparative Study 2011; 32(4): 428-436 PubMed PMID: 21876517  Keywords:  Adult, Anthropometry, Antipsychotic Agents:adverse effects, Benzodiazepines:adverse effects, Blood Glucose:drug effects, Clozapine:adverse effects, Female, Glucose Intolerance:chemically induced, Humans, Hyperprolactinemia:chemically induced, Insulin Resi.    Citation

OBJECTIVES: This study consisting of two subprojects was undertaken to evaluate the effects of hyperprolactinemia on cardiovascular diseas.....

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