: Cerebral infarction is a rare and severe manifestation of central nervous system damage caused by mycoplasma pneumoniae infection. We report that a 16-year-old girl was hospitalized with cough, expectoration and fever for 5 days and shortness of breath for 1 day. At the time of admission, the chest computed tomography showed double lung fields infiltration and pleural effusion. The detection of mycoplasma pneumoniae antibodies (IgG and IgM) were positive. The right limb movement of the patient was found incapacitated on the seventh day of hospitalization. Computed tomography, magnetic resonance imaging and magnetic resonance angiography of the head demonstrated the acute cerebral infarction after mycoplasma pneumoniae infection. Early anti-infective therapy, microcirculation improvement and rehabilitation treatment improved the prognosis of this child. Craniocerebral imaging examinations and laboratory tests are helpful for diagnosis. Early detection and treatment can improve the prognosis of patients.