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Klimek R. The use in obstetrics of quantum theory as well as modern technology to decrease the morbidity and mortality of newborns and mothers during iatrogenic induced delivery. Neuro Endocrinol Lett. 2001 Jan; 22(1): 5-8
OBJECTIVES: The study investigated, whether the FT4 and TSH blood levels in euthyroid pregnant women correlate with neonatal Apgar score. MATERIAL AND METHODS: The study group included 102 euthyroid pregnant women and their newborns. All women underwent clinical assessment (including pregnancy and perinatal interview and physical examination) and laboratory tests involving TSH and FT4 blood concentrations measurements three times, in each trimester. The neonate's overall condition was assessed with the Apgar scale. RESULTS: A significant positive correlation was described between FT4 concentrations in the study group in the first and second trimester and the newborns' condition assessed on the Apgar scale at 1 minute (Spearman's Rs rank correlation, R = 0.2418; p = 0.014 for the first trimester, and R = 0.2015; p = 0.043 for the second trimester); FT4 concentrations in the first trimester and Apgar score at 3 minutes (Spearman's Rs rank correlation, R = 0.2066; p = 0.038) and between FT4 in the second trimester and the results of Apgar score in the 5th minute (Spearman's Rs rank correlation, R = 0.2231; p = 0.024). Otherwise, maternal TSH concentrations did not significantly correlate with neonatal Apgar score. Analysis of the correlation between the tested thyroid hormones and the birth weight of newborns, as well as delivery date, did not show any significant correlations CONCLUSION: Our study disclosed the impact of maternal FT4 concentration on neonatal outcome expressed by Apgar score. The results presented reveal potential clinically relevant benefits derived from profound thyroid screening during pregnancy....
Paszyński P, Słopień R, Tomaszewska A, Owecka B, Kosal K, Owecki M. Maternal fT4 blood level during pregnancy in euthyroid pregnant women correlates positively with neonate's Apgar score. Neuro Endocrinol Lett. 2025 Nov; 46(4): 213-220
PURPOSE: To evaluate whether middle cerebral artery (MCA) Doppler flow parameters measured in the first week of life are associated with intraventricular hemorrhage (IVH) in preterm infants. METHODS: A prospective cohort study was conducted in a level 4A neonatal intensive care unit (NICU) at Adana City Training and Research Hospital between March 2022 and April 2023. Preterm infants born weighing ≤1250 g and ≥500 g were included. MCA flow parameters, including peak systolic velocity (PSV), peak diastolic velocity (PDV), pulsatility index (PI), resistivity index (RI) and time-averaged maximum velocity (TAMAX) were measured via transfontanel Doppler ultrasonography within the first five days of life every day. The association between MCA Doppler parameters and IVH development was analyzed. RESULTS: Ninety-two preterm infants were included. IVH was detected in 34.7% (n = 32). Infants with IVH had lower gestational age and birth weight. Logistic regression revealed that lower birth weight, the presence of PDA, and early-onset sepsis increased IVH risk. Both increased and decreased MCA Doppler parameters (PSV, PDV, PI and TAMAX) preceded IVH. CONCLUSION: MCA Doppler flow fluctuations were associated with IVH in preterm infants. These associations warrant further investigation to determine whether MCA Doppler measurements can prospectively identify infants at risk for IVH. WHAT IS KNOWN: Cerebral autoregulation is a developmental process that can be disrupted in neonates with congenital heart disease, hypoxic-ischemic encephalopathy, and those born preterm. WHAT IS NEW: Novel methods to assess cerebral autoregulation in these populations can be used to target patient-specific hemodynamic parameters....
Gülaşı S, Mert M, Çekinmez E, Başaranoğlu M. Association between middle cerebral artery doppler flow parameters and intraventricular hemorrhage in preterm infants. Neuro Endocrinol Lett. 2025 Nov; 46(4): 205-212