Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M.
Journal Article 2014; 35(Suppl 2): 105-113 PubMed PMID: 25638374 Keywords: Benzo(a)pyrene:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:metabolism, Humans, NADH, NADPH Oxidoreductases:metabolism,. CitationOBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activ.....
Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M. Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 105-113
Indra R, Moserova M, Sulc M, Frei E, Stiborova M.
Comparative Study 2013; 34(Suppl 2): 55-63 PubMed PMID: 24362093 Keywords: Animals, Benzo(a)pyrene:metabolism, Carcinogens:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:pharmacology, Humans, Inactivation, Metabolic, Male, Microsomes, Liver:drug effects, Oxidation-Reduction, Rats,. CitationOBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (B.....
Indra R, Moserova M, Sulc M, Frei E, Stiborova M. Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 55-63
Kolarik M, Indra R, Adam V, Heger Z, Kopeckova K, Arlt V, Stiborova M.
Journal Article 2019; 39(7): 515-524 PubMed PMID: 30860683 Keywords: Anilides:pharmacology, Animals, Cytochrome P-450 Enzyme Inhibitors:pharmacology, Ellipticines:pharmacokinetics, Humans, Microsomes, Liver:drug effects, Oxidation-Reduction:drug effects, Peroxidases:antagonists & inhibitors, Phenylurea Compounds:pharmacolo. CitationOBJECTIVES: Vandetanib¸ lenvatinib, and cabozantinib are tyrosine kinase inhibitors (TKIs) targeting VEGFR subtypes 1 and 2, EGFR and the.....
Kolarik M, Indra R, Adam V, Heger Z, Kopeckova K, Arlt V, Stiborova M. Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro. Neuro Endocrinol Lett. 2019 Feb; 39(7): 515-524