Articles by author - Lenka Dvorakova

Alternative methods in vitro for screening of endocrine disruptors.

Dvořáková M, Kejlová K, Bendová H, Rucki M, Kohout P, Vavrouš A, Jírová D.

Journal Article 2016; 37(Suppl 1): 123-131 PubMed PMID: 28263540  Keywords:  Benzhydryl Compounds:metabolism, Biological Assay, Cell Line, Endocrine Disruptors:metabolism, Estrogen Receptor alpha:agonists, Estrogens, Non-Steroidal:metabolism, Humans, Phenols:metabolism,.    Citation

OBJECTIVES: The aim of this study was to compare in silico data with results obtained in two alternative in vitro methods; and to investig.....

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Bioindicators of wastewater ecotoxicity.

Jirova G, Wittlingerova Z, Zimova M, Vlkova A, Wittlerova M, Dvorakova M, Jirova D.

Journal Article 2016; 37(Suppl 1): 17-24 PubMed PMID: 28263526  Keywords:  Animals, Biological Assay:methods, Environmental Monitoring, Fishes, Toxicity Tests:methods, Waste Water:toxicity, Water Pollutants, Chemical:toxicity,.    Citation

: Wastewater, especially containing hospital effluents, exhibits high chemical complexity and specificity since it includes vario.....

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Effect of repeated therapeutic horse riding sessions on the trunk movement of the rider.

Janura M, Svoboda Z, Cabell L, Dvoráková T, Jelen K.

Journal Article 2015; 36(5): 481-489 PubMed PMID: 26707049  Keywords:  Adult, Biomechanical Phenomena, Equine-Assisted Therapy, Female, Humans, Movement:physiology, Spine:physiology, Torso, Young Adult,.    Citation

OBJECTIVE: To assess the rider's movement during walking the horse in repeated therapeutic horse riding sessions and to determine the rela.....

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Eye irritation hazard of chemicals and formulations assessed by methods in vitro.

Jírová D, Kejlová K, Janoušek S, Bendová H, Malý M, Kolářová H, Dvořáková M.

Journal Article 2014; 35(Suppl 2): 133-140 PubMed PMID: 25638377  Keywords:  Animals, Cosmetics:toxicity, Eye Diseases:chemically induced, Humans, In Vitro Techniques, Irritants:toxicity, Skin Diseases:chemically induced,.    Citation

BACKGROUND: The aim of this study was to compare human and animal skin irritation data with results of selected in vitro methods,.....

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Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia.

Lochman J, Plesník J, Janout V, Povová J, Míšek I, Dvořáková D, Šerý O.

Journal Article 2013; 34(8): 792-797 PubMed PMID: 24522021  Keywords:  Adult, Epigenesis, Genetic:genetics, Genetic Predisposition to Disease:epidemiology, Genotype, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2):genetics, Middle Aged, Polymorphism, Genetic, Receptors, Adrenergic, alpha-2:genetics, Risk Factors, .    Citation

OBJECTIVES: Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved i.....

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Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.

Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M.

Journal Article 2011; 32(Suppl 1): 101-116 PubMed PMID: 22167207  Keywords:  Animals, Antineoplastic Combined Chemotherapy Protocols:pharmacology, Brain Neoplasms:drug therapy, DNA Damage, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Ellipticines:administration & dosage, Histone Deacetylase Inhibitors:administra.    Citation

OBJECTIVES: Valproic acid (VPA) and trichostatin A (TSA) exert antitumor activity as histone deacetylase inhibitors, whereas ellipticine a.....

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