Combined central and peripheral demyelination - one-year follow-up of patient with co-incidence of multiple sclerosis and multifocal acquired demyelinating sensory and motor neuropathy - A Case Report.

  Vol. 44 (6) 2023 Neuro endocrinology letters Case Reports   2023; 44(6): 345-350 PubMed PMID:  37776551    Citation

: Combined central and peripheral demyelination (CCPD) is a rare autoimmune neurologic disease, characterized by immune-mediated damage of myelin sheath at central and peripheral levels of the nervous system. The current knowledge about this disorder is only limited, mainly due to the low incidence of the disease. According to previous studies, CCPD has a very heterogeneous course, insufficient therapeutic response, and an unfavorable prognosis. We report on the 37-year-old patient with a coincidence of demyelinating lesions in the brain fulfilling current McDonald's diagnostic criteria for multiple sclerosis, as well as the presence of an atypical variant of chronic inflammatory demyelinating polyneuropathy (CIDP) - multifocal acquired demyelinating sensory-motor neuropathy (MADSAM), as a subtype of combined central and peripheral demyelination (CCPD).

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