Bombesin modulates the control of energy homeostasis and pituitary hormone release.

: Bombesin and related peptides are widely distributed in gastrointestinal tract and central nervous system. It has been reported that they play an important role in the control of appetite, metabolism, sensory transmission and thermoregulation as well as in the regulation of pituitary hormone release. Central injection of these peptides leads to inhibition of feeding. There are controversial opinions about the effects of bombesin on pituitary hormone secretion both in vivo and in vitro experiments.