Antinociceptive effects of cefadroxil and ceftriaxone in experimental animal models of pain.
BACKGROUND: As an "off-target" effect, cephalosporins can enhance glutamate transporter-1 expression in astrocytes to recycle glutamate from synaptic cleft, and exhibited analgesic properties in animals and humans with chronic pain. METHODS: In the present study, we focused on making a side-by-side comparison of the analges.....