Vol. 39 (7) 2018 Neuro endocrinology letters

Effects of peripheral administration of GH and IGF-I on gene expression in the hippocampus of hypophysectomised rats.

OBJECTIVE: Growth hormone (GH) increases insulin-like growth factor I (IGF-I) production and both hormones affect hippocampal plasticity. We have previously shown that Hbb and Alas2 in the rat hippocampus were robustly regulated by GH-infusions for six days, whereas other transcripts were weakly affected. Here, we explored the effects o.....