Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior.
OBJECTIVES: There are several models of depression. Chronic unpredictable mild stress (CMS) appears to have the greatest validity, although it is often being criticized for low reliability.
METHODS: Male Wistar/DV rats were used in this study to assess our modified 2-week model of CMS as a combinat.....