Vol. 35 (6) 2014 Neuro endocrinology letters

Dot1L mediated histone H3 lysine79 methylation is essential to meiosis progression in mouse oocytes.

OBJECTIVES: Post-translational modifications of lysine residues of histones can result in a series of functional changes. Lysine 79 of histone H3 (H3K79) can be methylated specifically by the Dot1 family of histone lysine methyltransferases. Although multiple developmental abnormalities in Dot1L-deficient mouse embryos have been studied.....