Vol. 35 (3) 2014 Neuro endocrinology letters

Insulin inhibits Abeta production through modulation of APP processing in a cellular model of Alzheimer's disease.

OBJECTIVE: Amyloid-beta (Abeta) is a 36-43 amino acid peptide that is derived by processing of the beta-amyloid precursor protein (APP). Abeta plays a central role in the development of Alzheimer's disease (AD). Although growing evidence suggests that insulin has important functions in Abeta metabolism, the underlying mechanisms are sti.....