Vol. 34 (Suppl 2) 2013 Neuro endocrinology letters

Tacrine alters antibodies level in Francisella tularensis-infected mice.

OBJECTIVES: Tacrine is an inhibitor of acetylcholinestrase (AChE) formerly used to treat cognitive impairment of Alzheimer disease. In previous works, we have shown that inhibitors of AChE can modulate innate immunity responses. In the present study we focused on modulation of adaptive immunity represented by production of antibodies. I.....