Vol. 34 (8) 2013 Neuro endocrinology letters

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia.

OBJECTIVES: Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in.....