Vol. 34 (6) 2013 Neuro endocrinology letters

Inherited thrombotic thrombocytopenic purpura in pregnancy.

OBJECTIVE: The primary pathologic reason for thrombotic thrombocytopenic purpura (TTP) lies in the systemic formation of platelet aggregations in association with endothelial cells damage. Endothelial damage is a result of an abnormal synthesis and metabolism of unusually large von Willebrand Factor (ULvWF) multimers. In normal conditio.....