Vol. 34 (5) 2013 Neuro endocrinology letters

The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil.

OBJECTIVE: Donepezil, a cholinesterase inhibitor (ChEI) that is widely used to treat Alzheimer's disease, is thought to act by increasing extracellular acethylcholine (ACh) in the central nervous system. The effects of the administration of ChEIs on the autonomic nervous system, however, are complex and controversial.