Vol. 34 (5) 2013 Neuro endocrinology letters

Nitrosative-induced posttranslational α-tubulin changes on high-glucose-exposed Schwannoma cell line.

OBJECTIVE: One of the major complications during prolonged hyperglycemic condition is the onset of the so-called diabetic neuropathy, that can affect the peripheral nervous system. Evidence has reported that glucose-induced oxidative stress could be a key mediator in this process, impairing the cytoskeletal structures, such as microtubu.....