Chronic exposure to benzyl butyl phthalate (BBP) alters social interaction and fear conditioning in male adult rats: alterations in amygdalar MeCP2, ERK1/2 and ERα.

Betz A, Jayatilaka S, Joshi J, Ramanan S, Debartolo D, Pylypiw H, Franke E.

Journal Article 2013; 34(5): 347-358 PubMed PMID: 23922038 Keywords: Amygdala:drug effects, Animals, Association Learning:drug effects, Behavior, Animal:drug effects, Conditioning (Psychology):drug effects, Estrogen Receptor alpha:metabolism, Fear:drug effects, MAP Kinase Signaling System:drug effects, Male, Methyl-CpG-Bin.

OBJECTIVES: Benzyl Butyl Phthalate (BBP) is an industrial plasticizer that has an unknown action in the central nervous system. Phthalates have recently been associated with behavioral actions that are linked to their endocrine disrupting properties. The purpose of this study was to investigate the behavioral and molecular effects of BB.....

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Vol. 34 (5) 2013 Neuro endocrinology letters

Chronic exposure to benzyl butyl phthalate (BBP) alters social interaction and fear conditioning in male adult rats: alterations in amygdalar MeCP2, ERK1/2 and ERα.

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