Vol. 33 (1) 2012 Neuro endocrinology letters

Study of the APC gene function in the mouse APC+/APC1638N model.

OBJECTIVES: Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the presence of hundreds to thousands of benign polyps in the colon. If not removed prophylactically they represent a risk of developing malignant cancer with an almost 100% penentrance. FAP is induced by germline mutation in the APC gene......