Vol. 32 (Suppl 1) 2011 Neuro endocrinology letters

Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.

OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder. Symptomatic treatment is available by inhibitors of acetylcholinesterase (AChE) such as rivastigmine, galantamine and donepezil. As huperzine is a promising compound for AD treatment, our study was aimed at evaluating its pertinent implications in oxidative stress.