Vol. 32 (Suppl 1) 2011 Neuro endocrinology letters

Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.

Hodek P, Krizkova J, Frei E, Singh R, Arlt V, Stiborova M.

Journal Article 2011; 32(Suppl 1): 25-34 PubMed PMID: 22167217 Citation  Keywords:  Animals, Carcinogens, Environmental:isolation & purification, Cytochrome P-450 CYP1A1:antagonists & inhibitors, DNA Damage:drug effects, Drug Evaluation, Preclinical, Enzyme Induction:drug effects, Enzyme Inhibitors:pharmacology, Food:toxicity, Food Conta.

OBJECTIVES: Benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are carcinogens, which frequently occur in the human diet. Their metabolic activation to reactive species binding to DNA is mediated by cytochromes P450 (CYPs) 1A1 and 1A2. Thus, levels and activities of these CYPs are crucial for initiation of B.....

Read abstract

The effects of Click 500 SC (terbuthylazine) on common carp Cyprinus carpio under (sub)chronic conditions.

Mikulíkova I, Modra H, Blahova J, Marsalek P, Groch L, Siroka Z, Kruzikova K, Jarkovsky J, Littnerova S, Svobodova Z.
Journal Article 2011; 32(Suppl 1): 15-24 PubMed PMID: 22167222 Citation  Keywords:  Alanine Transaminase:blood, Albumins:analysis, Animals, Antioxidants:metabolism, Carps:blood, Ceruloplasmin:metabolism, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Environmental Monitoring, Herbicides:pharmacology, Metabolome, Oxidatio.

Read abstract  Full text PDF

The effect of peroral administration of toxic cyanobacteria on laboratory rats (Rattus norvegicus var. alba).

Adamovsky O, Kopp R, Zikova A, Blaha L, Kohoutek J, Ondrackova P, Paskerova H, Mares J, Palikova M.
Evaluation Studies 2011; 32(Suppl 1): 35-45 PubMed PMID: 22167221 Citation  Keywords:  Administration, Oral, Animals, Animals, Laboratory, Bacterial Toxins:pharmacology, Cyanobacteria:pathogenicity, Eating:physiology, Fish Products:toxicity, Food Contamination, Glutathione:metabolism, Lipid Peroxidation:drug effects, Male, Marine Toxins:pha.

Read abstract  Full text PDF

Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver.

Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H.
Journal Article 2011; 32(Suppl 1): 121-130 PubMed PMID: 22167220 Citation  Keywords:  Animals, Aristolochic Acids:pharmacokinetics, Biotransformation, Carcinogens:pharmacokinetics, Cytochrome P-450 CYP1A1:genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System:genetics, Cytochromes:genetics, DNA Adducts:metabolism, Drug Evaluatio.

Read abstract  Full text PDF

Isolation and partial characterization of extracellular NADPH-dependent phenol hydroxylase oxidizing phenol to catechol in Comamonas testosteroni.

Turek M, Vilimkova L, Kremlackova V, Paca J, Halecky M, Paca J, Stiborova M.
Journal Article 2011; 32(Suppl 1): 137-145 PubMed PMID: 22167219 Citation  Keywords:  Catalysis, Catechols:metabolism, Chromatography, High Pressure Liquid, Cloning, Molecular, Comamonas testosteroni:enzymology, Electrophoresis, Polyacrylamide Gel, Extracellular Space:enzymology, Hydrogen-Ion Concentration, Mixed Function Oxygenases:geneti.

Read abstract  Full text PDF

Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level.

Pelclova D, Navratil T, Fenclova Z, Vlckova S, Kupka K, Urban P, Ridzon P, Zikan V, Landova L, Syslova K, Kuzma M, Kacer P.
Evaluation Studies 2011; 32(Suppl 1): 71-76 PubMed PMID: 22167218 Citation  Keywords:  Aged, Biomarkers:analysis, Blood Chemical Analysis:methods, Case-Control Studies, Chemical Industry, Female, Herbicides:analysis, Humans, Male, Middle Aged, Occupational Exposure:analysis, Osmolar Concentration, Oxidative Stress:physiology, Polychlorinate.

Read abstract  Full text PDF

Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.

Pohanka M, Hrabinova M, Zemek F, Drtinova L, Bandouchova H, Pikula J.
Journal Article 2011; 32(Suppl 1): 95-100 PubMed PMID: 22167216 Citation  Keywords:  Alkaloids:pharmacology, Animals, Antioxidants:metabolism, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, FMN Reductase:metabolism, Glutathione Reductase:metabolism, Guinea Pigs, Homeostasis:drug effects, Models, Animal, Models, Biological.

Read abstract  Full text PDF

Electrogastrography in experimental pigs: the influence of gastrointestinal injury induced by dextran sodium sulphate on porcine gastric erythromycin-stimulated myoelectric activity.

Tachecí I, Kvetina J, Kunes M, Edakkanambeth Varayil J, Ali S, Pavlik M, Kopacova M, Rejchrt S, Bures J, Pleskot M.
Journal Article 2011; 32(Suppl 1): 131-136 PubMed PMID: 22167215 Citation  Keywords:  Animals, Dextran Sulfate, Drug Evaluation, Preclinical, Electromyography:methods, Electrophysiological Phenomena:drug effects, Erythromycin:administration & dosage, Female, Gastrointestinal Agents:administration & dosage, Gastrointestinal Diseases:chemica.

Read abstract  Full text PDF

Effects of sublethal exposure of European brown hares to paraoxon on the course of tularemia.

Bandouchova H, Pohanka M, Kral J, Ondracek K, Osickova J, Damkova V, Vitula F, Treml F, Pikula J.
Comparative Study 2011; 32(Suppl 1): 77-83 PubMed PMID: 22167214 Citation  Keywords:  Acetylcholinesterase:blood, Animals, Antioxidants:metabolism, Caspase 3:blood, Cholinesterase Inhibitors:toxicity, Disease Reservoirs, Environmental Exposure, Francisella tularensis:pathogenicity, Hares, Insecticides:toxicity, Male, Paraoxon:toxicity, Ran.

Read abstract  Full text PDF

Effects of subchronic exposure to simazine on zebrafish (Danio rerio).

Plhalova L, Haluzova I, Macova S, Dolezelova P, Praskova E, Marsalek P, Skoric M, Svobodova Z, Pistekova V, Bedanova I.
Evaluation Studies 2011; 32(Suppl 1): 89-94 PubMed PMID: 22167213 Citation  Keywords:  Animals, Behavior, Animal:drug effects, Dose-Response Relationship, Drug, Environmental Exposure, Hepatocytes:drug effects, Herbicides:pharmacology, Kidney:drug effects, Simazine:pharmacology, Survival Analysis, Toxicity Tests, Subchronic:statistics & num.

Read abstract  Full text PDF

Effects of neurotoxin - anatoxin-a on common carp (Cyprinus carpio L.) innate immune cells in vitro.

Rymuszka A, Sieroslawska A.
Journal Article 2011; 32(Suppl 1): 84-88 PubMed PMID: 22167212 Citation  Keywords:  Animals, Blood Cells:drug effects, Carps:blood, Cells, Cultured, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Immunity, Innate:drug effects, Neurotoxins:pharmacology, Phagocytes:drug effects, Pronephros:cytology, Reactive Nitrogen Speci.

Read abstract  Full text PDF

Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats.

Matuskova Z, Siller M, Tunkova A, Anzenbacherova E, Zacharova A, Tlaskalova-Hogenova H, Zidek Z, Anzenbacher P.
Evaluation Studies 2011; 32(Suppl 1): 8-14 PubMed PMID: 22167211 Citation  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP2E1:genetics, Cytochrome P-450 CYP3A:genetics, Cytochrome P-450 Enzyme System:genetics, Cytochrome P450 Family 2, Cytochromes:genetics, Enzyme Activation:drug ef.

Read abstract  Full text PDF

Comparison of acute toxicity of ketoprofen to juvenile and embryonic stages of Danio rerio.

Praskova E, Voslarova E, Siroka Z, Macova S, Plhalova L, Bedanova I, Marsalek P, Pistekova V, Svobodova Z.
Comparative Study 2011; 32(Suppl 1): 117-120 PubMed PMID: 22167210 Citation  Keywords:  Animals, Anti-Inflammatory Agents, Non-Steroidal:adverse effects, Cell Membrane Permeability:drug effects, Cyclooxygenase Inhibitors:adverse effects, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Embryo, Nonmammalian, Ketoprofen:adverse .

Read abstract  Full text PDF

Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.

Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M.
Comparative Study 2011; 32(Suppl 1): 57-70 PubMed PMID: 22167209 Citation  Keywords:  Acetyltransferases:chemistry, Animals, Aristolochic Acids:chemistry, Biotransformation:physiology, Catalytic Domain, Cells, Cultured, DNA Adducts:metabolism, Enzyme Activation, Humans, Lactams:metabolism, Models, Molecular, Molecular Conformation, NAD(P)H.

Read abstract  Full text PDF

Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.

Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M.
Journal Article 2011; 32(Suppl 1): 101-116 PubMed PMID: 22167207 Citation  Keywords:  Animals, Antineoplastic Combined Chemotherapy Protocols:pharmacology, Brain Neoplasms:drug therapy, DNA Damage, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Ellipticines:administration & dosage, Histone Deacetylase Inhibitors:administra.

Read abstract  Full text PDF

Absorption kinetics of 5-aminosalicylic acid in rat: influence of indomethacin-induced gastrointestinal lesions and Escherichia Coli Nissle 1917 medication.

Kunes M, Kvetina J, Kholova D, Bures J, Tlaskalova-Hogenova H, Pavlik M.
Evaluation Studies 2011; 32(Suppl 1): 46-52 PubMed PMID: 22167206 Citation  Keywords:  Absorption, Animals, Anti-Inflammatory Agents, Non-Steroidal:adverse effects, Escherichia coli:physiology, Gastrointestinal Diseases:chemically induced, Gastrointestinal Tract:drug effects, Indomethacin:adverse effects, Kinetics, Male, Mesalamine:blood, O.

Read abstract  Full text PDF