N-acetylserotonin reduces lipopolysaccharide-induced lipid peroxidation in vitro more effectively than melatonin.

Stuss M, Wiktorska J, Sewerynek E.

Journal Article 2010; 31(4): 489-496 PubMed PMID: 20802448 Keywords: Analysis of Variance, Animals, Brain:drug effects, Kidney:drug effects, Lipid Peroxidation:drug effects, Lipopolysaccharides:pharmacology, Liver:drug effects, Male, Malondialdehyde:metabolism, Melatonin:pharmacology, Rats, Rats, Wistar, Serotonin:analogs .

OBJECTIVE: Bacterial lipopolysaccharide (LPS) causes lipid peroxidation (LPO). We have found that LPS induces LPO in vitro, in tissue homogenates in a concentration-dependent manner, the concentration of 400 µg/ml demonstrating the most efficient lipid damaging effect . Both melatonin and its precursor, N-acetylserotonin, must posses.....

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Vol. 31 (4) 2010 Neuro endocrinology letters

N-acetylserotonin reduces lipopolysaccharide-induced lipid peroxidation in vitro more effectively than melatonin.

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