Effects of growth hormone and insulin-like growth factor-I on the iron-induced lipid peroxidation in the rat liver and porcine thyroid homogenates.

Kokoszko A, Dabrowski J, Lewiński A, Karbownik-Lewińska M.

Journal Article 2010; 31(4): 517-523 PubMed PMID: 20802456 Keywords: Analysis of Variance, Animals, Ferrous Compounds:pharmacology, Growth Hormone:pharmacology, Insulin-Like Growth Factor I:pharmacology, Lipid Peroxidation:drug effects, Liver:drug effects, Malondialdehyde:metabolism, Rats, Swine, Thyroid Gland:drug effects.

OBJECTIVES: Growth hormone (GH) and its tissue mediator, insulin-like growth factor-I (IGF-I), are involved in oxidative processes, lipid peroxidation (LPO) included. Bivalent iron (Fe2+) is frequently used to experimentally induce oxidative damage to macromolecules (Fe2++H2O2+H+→Fe3++•OH+H2O). The aim of the study was to evaluate t.....

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Vol. 31 (4) 2010 Neuro endocrinology letters

Effects of growth hormone and insulin-like growth factor-I on the iron-induced lipid peroxidation in the rat liver and porcine thyroid homogenates.

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