Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation.

Xu T, Ye F, Wang B, Tian C, Wang S, Shu K, Guo D, Lei T.

Comparative Study 2010; 31(1): 147-154 PubMed PMID: 20150876 Keywords: Acromegaly:etiology, Adenoma:complications, Adult, Female, GTP-Binding Protein alpha Subunits:genetics, Ghrelin:genetics, Growth Hormone-Secreting Pituitary Adenoma:complications, Humans, Male, Middle Aged, Mutation, RNA, Messenger:metabolism, Receptors, .

OBJECTIVE: The purpose of this study was to investigate the relationship between the ghrelin or GHSR-1a mRNA levels and clinical characteristics and to confirm the effect of gsp mutations on ghrelin/GHSR-1a system in human GH-secreting pituitary adenomas.

METHODS: The expression levels of ghrelin, GHSR-1a mRNA we.....

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Vol. 31 (1) 2010 Neuro endocrinology letters

Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation.

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