Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.

Journal Article 2009; 30(6): 715-722 PubMed PMID: 20035260 Keywords: Adult, Biomarkers:blood, Cardiovascular Diseases:epidemiology, Creatinine:urine, DNA Damage:physiology, Depressive Disorder, Major:epidemiology, Enzyme-Linked Immunosorbent Assay, Fatigue Syndrome, Chronic:epidemiology, Female, Guanine:analogs & derivativ.

BACKGROUND: There is now evidence that major depression and myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are accompanied by partially overlapping pathophysiological mechanisms, i.e. activation of various inflammatory and oxidative & nitrosative (IO&NS) pathways.

OBJECTIVE: The aim of the present .....

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Vol. 30 (6) 2009 Neuro endocrinology letters

Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

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