7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid.
OBJECTIVE: Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity.
METHODS: In the ventricular cerebrospinal fluid obtained from 15 patients with hydrocephalus (8 post.....