Vol. 26 (2) 2005 Neuro endocrinology letters

Association between human leukocyte antigen (HLA) and interferon- induced thyroid diseases in four patients with HCV-related chronic hepatitis.

OBJECTIVES: The interferon-alpha (IFN-alpha) therapy for HCV hepatitis may exacerbate or induce underlying thyroid disorders. Besides viral factors, the human leukocyte antigen (HLA) may be an independent risk factor.

METHODS: We evaluated fifteen patients with HCV chronic hepatitis during a period of 40 months. .....