Vol. 25 (6) 2004 Neuro endocrinology letters

Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats.

OBJECTIVE: To examine the effect of ipamorelin (IPA), a novel pentapeptide with a strong growth hormone releasing potency, on insulin secretion from pancreatic tissue fragments of normal and diabetic rats.

MATERIALS AND METHODS: Diabetes mellitus was induced by streptozotocin (60 mg kg(-1)). Four weeks after the .....