Vol. 21 (3) 2000 Neuro endocrinology letters

The opposite effect of morning or afternoon application of melatonin on collagen accumulation in the sponge-induced granuloma.

: OBJECTIVES: Collagen accumulation in the sponge-induced granuloma is under inhibitory influence of melatonin. This effect was observed when the pineal hormone was injected late in the afternoon. DESIGN: The present study was conducted to compare the afternoon and morning melatonin application and to answer the question whether melaton.....