Vol. 20 (3-4) 1999 Neuro endocrinology letters

New analogs of somatostatin: inhibiting effectively GH, glucagon and insulin levels.

: The in vivo effects of three new analogs of somatostatin (ASS-51, ASS-52 and ASS-53 analogs) on GH, insulin and glucagon were studied in WKY rats. The solid phase method was used for the synthesis of ASS. Octreotide and ASS were given iv. in a dose of 0.05 &mgr;g/kg per animal in a time-dependent manner. ASS-52 and ASS-53 were longer .....