Vol. 20 (3-4) 1999 Neuro endocrinology letters

Effects of melatonin on 24-h rhythms of neuroendocrine and immune changes in Freund's adjuvant-induced arthritis.

: Old rats had significantly lower values of the amplitude of pineal melatonin content at any time point studied. Complete Freund's adjuvant administration reduced the amplitude of melatonin rhythm. On day 18 of arthritis development, decreased pineal melatonin contents were also seen in young rats. On day 18, a global depressive effect.....