Articles by author - Filip Zemek

Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration.

Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K.

Comparative Study 2013; 34(Suppl 2): 74-78 PubMed PMID: 24362096  Keywords:  Absorption, Animals, Biological Availability, Chlorides:administration & dosage, Cholinesterase Reactivators:administration & dosage, Female, Injections, Intramuscular, Injections, Intravenous, Oximes:administration & dosage, Pyridinium Compounds:administ.    Citation

OBJECTIVES: Oxime HI-6 is an acetylcholinesterase reactivator therapeutically efficient against nerve agents. Because of their physico-che.....

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Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.

Pohanka M, Hrabinova M, Zemek F, Drtinova L, Bandouchova H, Pikula J.

Journal Article 2011; 32(Suppl 1): 95-100 PubMed PMID: 22167216  Keywords:  Alkaloids:pharmacology, Animals, Antioxidants:metabolism, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, FMN Reductase:metabolism, Glutathione Reductase:metabolism, Guinea Pigs, Homeostasis:drug effects, Models, Animal, Models, Biological.    Citation

OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder. Symptomatic treatment is available by inhibitors of acetylcholineste.....

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