Articles by author - Jana Pavlickova

Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver.

Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H.

Journal Article 2011; 32(Suppl 1): 121-130 PubMed PMID: 22167220  Keywords:  Animals, Aristolochic Acids:pharmacokinetics, Biotransformation, Carcinogens:pharmacokinetics, Cytochrome P-450 CYP1A1:genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System:genetics, Cytochromes:genetics, DNA Adducts:metabolism, Drug Evaluatio.    Citation

OBJECTIVE: The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid ne.....

Read abstract  Full text PDF