Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol.

Soukupová M, Palazzo E, De Chiaro M, Gatta L, Migliozzi A, Guida F, Luongo L, Giordano C, Siniscalco D, De Novellis V, Marabese I, Krsiak M, Maione S.

Journal Article 2010; 31(4): 507-511 PubMed PMID: 20802454 Keywords: Acetaminophen:pharmacology, Amidohydrolases:antagonists & inhibitors, Analgesics, Non-Narcotic:pharmacology, Animals, Benzamides:pharmacology, Carbamates:pharmacology, Dose-Response Relationship, Drug, Drug Interactions, Linear Models, Male, Mice, Pain Me.

OBJECTIVES: Paracetamol is converted to an active metabolite AM404 via fatty acid amide hydrolase (FAAH). The aim of the present study was to ascertain whether a FAAH inhibitor URB597 antagonizes paracetamol analgesic activity (and to asses by this way the role of FAAH in analgesic activity of paracetamol).

METHODS:&n.....

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Vol. 31 (4) 2010 Neuro endocrinology letters

Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol.

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