Vol. 25 (5) 2004 Neuro endocrinology letters

Effects of long-term use Topiramate on fertility and growth parameter in adult male rats.

PURPOSE: A case control study was conducted to assess the effects of long-term ingestion of Topiramate on fertility, body and reproductive organ weight and level of sex hormones in Sprague-Dawley male rats.

METHODS: Ten adult male rats were exposed to Topiramate diets at a concentration of 100 mg /kg for 60 days......