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NEUROENDOCRINOLOGY LETTERS
including Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X

NEL Vol.24 No.1/2, Feb-Apr 2003

ORIGINAL ARTICLE

Dental amalgam as one of the risk factors in autoimmune diseases

2003; 24:65–67
pii: NEL241203A09
PMID: 12743535

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Dental amalgam as one of the risk factors in autoimmune diseases

Jirina Bártová 1, Jarmila Procházková 1, Zuzana Krátká 1,
Klára Benetková 1, Zora Venclíková 1 & Ivan Šterzl 2

1. Institute of Dental Research, lst Medical Faculty, Charles University and General Faculty Hospital Prague, CZECH REPUBLIC.
2. Institute of Endocrinology, Prague, CZECH REPUBLIC.

Submitted: November 3, 2002 Accepted: November 12, 2002

Key words:
Antinuclear autoantibodies, HgCl2 response, peripheral blood mononuclear cells, thyroiditis

 

Abstract

BACKGROUND: Experimental and clinical data published recently show that dental amalgam can give rise to undesirable immunological responses in susceptible individuals. In genetically susceptible strains of experimental animals, mercury and silver can induce autoimmune responses. Sera of patients sensitive to mercury were found to have a higher incidence of autoantibodies relative to controls.

OBJECTIVE: The aim of this study was to determine possible presence of antinuclear SSB/La autoantibodies after the in vitro stimulation of peripheral blood lymphocytes with HgCl2.

METHODS: Lymphocytes were obtained from patients with autoimmune thyroiditis and increased response to mercury in vitro. Mononuclear cells were cultivated for 6 days with 100 ml HgCl2 solution or with pure medium and the levels of antinuclear autoantibodies SSB/La were assayed by a commercial SSB/La ELISA kit.

RESULTS: Increased production of SSB/La autoantibodies in the media following stimulation of peripheral blood lymphocytes with HgCl2 was found in all cases. Using the Student's paired test, the results were significant on the p=0.05 significance level.

CONCLUSION: Results imply that, in some patients with thyroiditis, mercury from dental amalgam can stimulate the production of antinuclear antibodies. Dental amalgam may be a risk factor in some patients with autoimmune disease.

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