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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 No.1/2, Feb-Apr 2003
ORIGINAL ARTICLE
Dental
amalgam as one of the risk factors in autoimmune diseases
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2003;
24:65–67
pii: NEL241203A09
PMID: 12743535
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Dental
amalgam as one of the risk factors in autoimmune diseases
Jirina
Bártová 1, Jarmila Procházková
1, Zuzana Krátká 1,
Klára Benetková 1, Zora Venclíková
1 & Ivan Šterzl 2
1.
Institute of Dental Research, lst Medical Faculty, Charles
University and General Faculty Hospital Prague,
CZECH REPUBLIC.
2. Institute of Endocrinology, Prague, CZECH REPUBLIC.
Submitted:
November 3, 2002 Accepted: November 12, 2002
Key
words:
Antinuclear autoantibodies, HgCl2
response, peripheral blood mononuclear cells, thyroiditis
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Abstract
BACKGROUND:
Experimental and clinical data published recently show that
dental amalgam can give rise to undesirable immunological
responses in susceptible individuals. In genetically susceptible
strains of experimental animals, mercury and silver can induce
autoimmune responses. Sera of patients sensitive to mercury
were found to have a higher incidence of autoantibodies relative
to controls.
OBJECTIVE:
The aim of this study was to determine possible presence of
antinuclear SSB/La autoantibodies after the in vitro stimulation
of peripheral blood lymphocytes with HgCl2.
METHODS:
Lymphocytes were obtained from patients with autoimmune thyroiditis
and increased response to mercury in vitro. Mononuclear cells
were cultivated for 6 days with 100 ml HgCl2 solution or with
pure medium and the levels of antinuclear autoantibodies SSB/La
were assayed by a commercial SSB/La ELISA kit.
RESULTS:
Increased production of SSB/La autoantibodies in the media
following stimulation of peripheral blood lymphocytes with
HgCl2 was found in all cases. Using the Student's paired test,
the results were significant on the p=0.05 significance level.
CONCLUSION:
Results imply that, in some patients with thyroiditis, mercury
from dental amalgam can stimulate the production of antinuclear
antibodies. Dental amalgam may be a risk factor in some patients
with autoimmune disease.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
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without prior written permission from the Editor-in-Chief.
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