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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 No.1/2, Feb-Apr 2003
ORIGINAL ARTICLE
GABAergic
and Serotoninergic systems on Hypothalamic Catecholamines
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2003;
24:46–49
pii: NEL241203A06
PMID: 12743531
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Effects
of gabaergic and serotoninergic systems on hypothalamic content
of catecholamines during sexual development in female rats
Dora
Rondina, Osvaldo J. Ponzo, Berta Szwarcfarb,
Silvia Carbone, Pablo Scacchi* & Jaime A. Moguilevsky*
Departamento
de Fisiología, Facultad de Medicina, Universidad de Buenos
Aires. Buenos Aires, ARGENTINA.
* Established Investigator. National Research Council. Buenos
Aires Argentina
Submitted:
October 10, 2002 Accepted: November 11, 2002
Key
words:
puberty, serotonin, GABA, catecholamines
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Abstract
OBJECTIVES:
The aim of the present investigation was to determine whether
the catecholaminergic system is involved in gabaergic and
serotoninergic effects on gonadotrophin secretion during sexual
development. To this end, we studied the effect of GABAergic
and serotoninergic systems on hypothalamic catecholamine content
at different stages of sexual development.
METHODS:
The effect of GABA A and GABA B agonists and 5-hydroxy-L-tryptophan
on hypothalamic noradrenaline and dopamine content were determined
in prepubertal (16 days old) and peripubertal (30 days old)
rats.
RESULTS:
At 16 days of age GABA agonists did not modify hypothalamic
noradrenaline content, whereas a significant decrease in catecholamine
concentration was observed in peripubertal rats at 30 days
of age. Similar changes were observed with GABA agonists administration
on dopamine hypothalamic levels, i.e no effects at 15 days
of age and a significant decrease at 30 days. The administration
of 5-hydroxy-l-tryptophan (5-HTP) induced a decrease of hypothalamic
concentration of noradrenaline and dopamine at both ages.
CONCLUSION:
Results indicate that the GABAergic system modifies the hypothalamic
catecholamine content in peripubertal but not in prepubertal
rats while serotonin has an inhibitory effect at both stages
of sexual maturation. Even though both systems induce similar
ontogenic modifications on the gonadotrophin axis (stimulatory
effect in prepubertal and inhibitory action in peripubertal
and adult rats) the present results appear to indicate that
GABAergic and serotoninergic systems regulate gonadotrophin
secretion by different hypothalamic mechanisms.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means,
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without prior written permission from the Editor-in-Chief.
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