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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

NEUROENDOCRINOLOGY LETTERS
including Psychoneuroimmunology, Neuro
psychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology
ISSN 0172–780X

NEL Vol.23 No.2, April 2002

ORIGINAL ARTICLE
"Non-Seasonal Depression
and BLT "

2002; 23:109-113
pii: NEL220601A04
PMID:

full text pdf [504 kb]


Bright Light Therapy and/or Imipramine for Inpatients with Recurrent Non-Seasonal Depression

Abstract | Introduction | Subject and Method | Results
Discussion | References


Jan Prasko, Jiri Horacek, Jan Klaschka, Jirina Kosova,
Ivana Ondrackova & Jiri Sipek

Head of the Psychiatric Centre Prague: Prof. MUDr. Cyril Höschl, DrSc.
Psychiatric centre Prague, Ustavni 91, Prague - 8, 181 03 Czech Republic
3rd Medical faculty Charles University Prague, Centre of Neuropsychiatric Studies

Submitted: January 19, 2002
Accepted: January 23, 2002

Key words:
Major depressive disorder, inpatients, bright light therapy, imipramine, combination, clinical trial


Abstract

INTRODUCTION: The aim of a double-blind study was to assess the efficacy of bright light therapy and/or imipramine in the treatment of inpatients suffering with recurrent non-seasonal major depressive disorder.

METHOD: 34 in-patients with DSM-III-R diagnosis of major depressive disorder, recurrent type, were randomly allocated into 3 treatment groups. After 4-day washout period with baseline assessment they underwent 3 weeks of different types of treatment:
a) Group A: bright light therapy (5000 lux from 6-8 a.m.) and imipramine 150 mg/day.
b) Group B: bright light therapy (5000 lux from 6-8 a.m.) and imipramine-like placebo.
c) Group C: dim red light (500 lux from 6-8 a.m.) and imipramine 150 mg/day.
Outcome measures included weekly Hamilton Psychiatric Rating Scale for Depression, Clinical Global Impression Scale, Montgomery and Asberg Psychiatric Rating Scale for Depression and Beck Depression Inventory.

RESULTS: Patients of all three groups improved significantly. The improvement of the patients of group B treated with bright light therapy plus placebo was superior to the other two groups, but not significantly.

CONCLUSION: Bright light therapy can be effective in the treatment of non-seasonal major depressive disorder.

Introduction

Depression is a common disorder, with serious consequences for a high proportion of patients. Indeed, it is estimated that 2.6 - 6.2% of the general population experience depression in any given year [1] and that 15% of those who develop severe and recurrent illness eventually take their own lives [2]. Unfortunately, although ranges of effective antidepressant agents are available, many require an administration period of at least 2 weeks, and some up to 4 weeks, before a therapeutic effect is seen [3]. Bright light is a unique treatment method, which is effective and well tolerated and has an early onset of action, in the treatment of patients with Seasonal affective disorder [4, 5]. Some studies reported an antidepressant effect of bright light also in non-seasonal depression (non-SAD) [6, 7, 8]. However, the reports concerning the effect of a short-term administration of bright light on non-SAD depression are controversial. The aim of our double-blind study was to compare the effect of a three week bright light therapy and/or imipramine in the treatment of inpatients suffering with recurrent non-seasonal major depressive disorder.

Subject and Methods
The inclusion criteria ... ...
Exclusion criteria: ... ...
Light specifications: ... ...
Main outcome measures: ... ...
Statistical analysis: ... ...

Results
... ...

Discussion
... ...

Acknowledgement
Supported by grant CNS LN00B12 MSMT CR and by grant IGA: 870-2.

 


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