Synthetic
tetrapeptide epitalon restores disturbed neuroendocrine
regulation in senescent monkeys
by Vladimir Khavinson, Nadezhda Goncharova & Boris Lapin
Keywords:
Epitalon, melatonin, cortisol, circadian
rhythms, monkeys
Submitted:
June 22, 2001
Accepted: June 28, 2001
Abstract:
The OBJECTIVE of this research was to investigate the
regulatory effect of Epitalon on the production of melatonin
and cortisol in senescent monkeys.
MATERIAL
AND METHODS: We investigated the character of melatonin and
cortisol secretion by immunoferment assay in Epitalon-administered
female Macaca mulatta in different age periods.
RESULTS:
Epitalon was proven to significantly stimulate melatonin synthesis
in senescent monkeys in the evening, thereby normalising the
circadian rhythm of cortisol secretion.
