Focal ischemia in the cerebral cortex has an effect on the
neurohypophysis
II. Angiogenesis in the neurohypophysis is a consequence of
the focal ischemia in the cerebral cortex
by Malgorzata
Frontczak-Baniewicz & Barbara Gajkowska
Keywords:
capillary vessel, basement
membrane, extracellular matrix, angiogenesis
Submitted:
February 14, 2001
Accepted: March 16, 2001
Abstract:
OBJECTIVES:
Focal ischemia in the cerebral cortex has an effect on neurohypophysis.
The morphological changes of microvessels of neurohypophysis
were evaluated in a model of the cerebral infarction initiated
by a photochemical reaction in the cerebral cortex. After
photochemically induced platelet aggregation, we observed
the morphological features of angiogenesis.
METHOD: The model of photochemically-induced cerebral ischemia
was used. Seven days after intravenous injection of rose bengal
and irradiation from a halogen lamp source through an intact
cranium, the sampled material from neurohypophysis is processed
for transmission electron microscopy using standard procedures.
RESULTS: We observed morphological features of the new vessel
formation: the alterations in the endothelium and extracellular
matrix during separation of the endothelial cell from each
other in a “mother” vessel, the migration of the
endothelial cells in the extracellular matrix, the communication
of the lumen of the new and the “mother” vessels.
CONCLUSION: We observed development of the angiogenic phenotype
in the neurohypophysis after focal ischemia in the cerebral
cortex. The endothelium, basement membrane and extracellular
matrix undergo morphological alterations which lead to new
blood vessel formation.
