Identification of Key Regulatory Genes Involved in Pyroptosis in Osteoarthritis Through Integrated Single-Cell Transcriptomic and Machine Learning Analysis.
OBJECTIVE: This study aimed to identify pyroptosis related genes (pyroptosis RGs) in osteoarthritis (OA) and to evaluate their potential as candidate biomarkers by integrating bulk transcriptomic analysis, machine learning, and single cell RNA sequencing. METHODS: Bulk RNA sequencing datasets (GSE55235 and GSE55457) and a .....