Jerabek P, Martinek V, Stiborova M.
Journal Article 2012; 33(Suppl 3): 25-32 PubMed PMID: 23353840 Keywords: Amino Acid Sequence, Aristolochia:chemistry, Aristolochic Acids:adverse effects, Aryl Hydrocarbon Hydroxylases:chemistry, Catalytic Domain:drug effects, Computer Simulation, Cytochrome P-450 CYP1A1:chemistry, Cytochrome P-450 CYP1A2:chemistry, Cytochrome . CitationOBJECTIVES: The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid n.....
Jerabek P, Martinek V, Stiborova M. Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 25-32
Groh T, Hrabeta J, Poljakova J, Eckschlager T, Stiborova M.
Journal Article 2012; 33(Suppl 3): 16-24 PubMed PMID: 23353839 Keywords: Antineoplastic Agents, Phytogenic:pharmacology, Apoptosis:drug effects, Bone Marrow Neoplasms:drug therapy, Brain Neoplasms:drug therapy, Cell Cycle:drug effects, Cell Line, Tumor, Drug Resistance, Neoplasm:drug effects, Drug Synergism, Etoposide:pharmaco. CitationOBJECTIVES: Etoposide (Vepesid, VP-16), an inhibitor of topoisomerase II, is a chemotherapeutic drug commonly used for treatment of differ.....
Groh T, Hrabeta J, Poljakova J, Eckschlager T, Stiborova M. Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 16-24
Stiborova M, Cechova T, Borek-Dohalska L, Moserova M, Frei E, Schmeiser H, Paca J, Arlt V.
Journal Article 2012; 33(Suppl 3): 8-15 PubMed PMID: 23353838 Keywords: Aerobiosis:physiology, Air Pollutants:pharmacokinetics, Anaerobiosis:physiology, Animals, Benz(a)Anthracenes:pharmacokinetics, Carcinogens:pharmacokinetics, Cytochrome P-450 Enzyme System:metabolism, Cytochrome-B(5) Reductase:genetics, DNA Adducts:metabol. CitationOBJECTIVES: 2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. Its isomer 3-nitrobenzanthrone (3-NB.....
Stiborova M, Cechova T, Borek-Dohalska L, Moserova M, Frei E, Schmeiser H, Paca J, Arlt V. Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 8-15
Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H.
Journal Article 2011; 32(Suppl 1): 121-130 PubMed PMID: 22167220 Keywords: Animals, Aristolochic Acids:pharmacokinetics, Biotransformation, Carcinogens:pharmacokinetics, Cytochrome P-450 CYP1A1:genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System:genetics, Cytochromes:genetics, DNA Adducts:metabolism, Drug Evaluatio. CitationOBJECTIVE: The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid ne.....
Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H. Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 121-130
Turek M, Vilimkova L, Kremlackova V, Paca J, Halecky M, Paca J, Stiborova M.
Journal Article 2011; 32(Suppl 1): 137-145 PubMed PMID: 22167219 Keywords: Catalysis, Catechols:metabolism, Chromatography, High Pressure Liquid, Cloning, Molecular, Comamonas testosteroni:enzymology, Electrophoresis, Polyacrylamide Gel, Extracellular Space:enzymology, Hydrogen-Ion Concentration, Mixed Function Oxygenases:geneti. CitationOBJECTIVE: Comamonas testosteroni Pb50 is a microorganism that possesses high tolerance for phenol and shows strong phenol degrading activ.....
Turek M, Vilimkova L, Kremlackova V, Paca J, Halecky M, Paca J, Stiborova M. Isolation and partial characterization of extracellular NADPH-dependent phenol hydroxylase oxidizing phenol to catechol in Comamonas testosteroni. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 137-145
Hodek P, Krizkova J, Frei E, Singh R, Arlt V, Stiborova M.
Journal Article 2011; 32(Suppl 1): 25-34 PubMed PMID: 22167217 Keywords: Animals, Carcinogens, Environmental:isolation & purification, Cytochrome P-450 CYP1A1:antagonists & inhibitors, DNA Damage:drug effects, Drug Evaluation, Preclinical, Enzyme Induction:drug effects, Enzyme Inhibitors:pharmacology, Food:toxicity, Food Conta. CitationOBJECTIVES: Benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are carcinogens, which frequently occur in the.....
Hodek P, Krizkova J, Frei E, Singh R, Arlt V, Stiborova M. Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 25-34