OBJECTIVES: There is evidence that inflammatory, oxidative and nitrosative stress (IO&NS) pathways participate in the pathophysiology of a.....
Maes M, Leunis J. Attenuation of autoimmune responses to oxidative specific epitopes, but not nitroso-adducts, is associated with a better clinical outcome in Myalgic Encephalomyelitis/chronic fatigue syndrome. Neuro Endocrinol Lett. 2014 Jan; 35(7): 577-585
Maes M, Leunis J, Geffard M, Berk M.
Journal Article 2014; 35(6): 445-453 PubMed PMID: 25433843 Keywords: Adult, Antibodies, Bacterial:blood, Bacterial Translocation:immunology, Cluster Analysis, Fatigue Syndrome, Chronic:complications, Female, Humans, Immunoglobulin A:blood, Immunoglobulin M:blood, Irritable Bowel Syndrome:complications, Lipopolysaccharides:. CitationBACKGROUND: There is evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by gastro-intestinal symptom.....
Maes M, Leunis J, Geffard M, Berk M. Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome. Neuro Endocrinol Lett. 2014 Jan; 35(6): 445-453
BACKGROUND: There is now evidence that an increased translocation of LPS from gram negative bacteria with subsequent gut-derived inflammat.....
Maes M, Leunis J. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec; 29(6): 902-910
Maes M, Mihaylova I, Kubera M, Leunis J.
Journal Article 2008; 29(3): 313-319 PubMed PMID: 18580855 Keywords: Adult, Analysis of Variance, Blood-Air Barrier:physiology, Depressive Disorder, Major:complications, Fatigue Syndrome, Chronic:complications, Female, Humans, Immunoglobulin A:immunology, Immunoglobulin M:immunology, Intestinal Mucosa:physiology, Male, Mid. CitationBACKGROUND: It has been shown that chronic fatigue syndrome (CFS) and major depression (MDD) are accompanied by signs of oxidative stress .....
Maes M, Mihaylova I, Kubera M, Leunis J. An IgM-mediated immune response directed against nitro-bovine serum albumin (nitro-BSA) in chronic fatigue syndrome (CFS) and major depression: evidence that nitrosative stress is another factor underpinning the comorbidity between major depression and CF Neuro Endocrinol Lett. 2008 Jun; 29(3): 313-319
: There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro.....
Maes M, Kubera M, Leunis J. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008 Feb; 29(1): 117-124
Maes M, Mihaylova I, Leunis J.
Journal Article 2007; 28(6): 861-867 PubMed PMID: 18063934 Keywords: Adult, Analysis of Variance, Antibody Formation:immunology, Autoimmunity:immunology, Depression:blood, Depressive Disorder, Major:blood, Fatigue:blood, Fatigue Syndrome, Chronic:blood, Female, Humans, Immunoglobulin M:blood, Male, Middle Aged, Neuropsycho. Citation: Major depression and chronic fatigue syndrome (CFS) are accompanied by signs of oxidative and nitrosative stress (O&NS) and an inflammat.....
Maes M, Mihaylova I, Leunis J. Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and dep Neuro Endocrinol Lett. 2007 Dec; 28(6): 861-867