Maes M, Mihaylova I, Kubera M, Leunis J.
Journal Article 2008; 29(3): 313-319 PubMed PMID: 18580855 Keywords: Adult, Analysis of Variance, Blood-Air Barrier:physiology, Depressive Disorder, Major:complications, Fatigue Syndrome, Chronic:complications, Female, Humans, Immunoglobulin A:immunology, Immunoglobulin M:immunology, Intestinal Mucosa:physiology, Male, Mid. CitationBACKGROUND: It has been shown that chronic fatigue syndrome (CFS) and major depression (MDD) are accompanied by signs of oxidative stress .....
Maes M, Mihaylova I, Kubera M, Leunis J. An IgM-mediated immune response directed against nitro-bovine serum albumin (nitro-BSA) in chronic fatigue syndrome (CFS) and major depression: evidence that nitrosative stress is another factor underpinning the comorbidity between major depression and CF Neuro Endocrinol Lett. 2008 Jun; 29(3): 313-319
: There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro.....
Maes M, Kubera M, Leunis J. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008 Feb; 29(1): 117-124
Maes M, Mihaylova I, Ruyter M, Kubera M, Bosmans E.
Journal Article 2007; 28(6): 826-831 PubMed PMID: 18063923 Keywords: Adult, Anti-Inflammatory Agents:immunology, Cytokines:immunology, Depressive Disorder:metabolism, Female, Gene Expression Regulation:immunology, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase:immunology, Inflammation:metabolism, Interferon-gamma:immunology,. Citation: Immune activation is accompanied by induction of indoleamine (2,3)-dioxygenase (IDO), an enzyme which degrades tryptophan, a phenomenon .....
Maes M, Mihaylova I, Ruyter M, Kubera M, Bosmans E. The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation. Neuro Endocrinol Lett. 2007 Dec; 28(6): 826-831
Maes M, Mihaylova I, Kubera M, Bosmans E.
Comparative Study 2007; 28(6): 875-880 PubMed PMID: 18063921 Keywords: Adult, Analysis of Variance, Arachidonic Acid:administration & dosage, Cytokines:immunology, Depression:drug therapy, Docosahexaenoic Acids:administration & dosage, Dose-Response Relationship, Drug, Eicosapentaenoic Acid:administration & dosage, Female, H. CitationBACKGROUND: We have shown that a depletion of omega3 polysaturated fatty acids (PUFAs) plays a role in the pathophysiology of depression, .....
Maes M, Mihaylova I, Kubera M, Bosmans E. Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. Neuro Endocrinol Lett. 2007 Dec; 28(6): 875-880
Maes M, Mihaylova I, Kubera M, Bosmans E.
Journal Article 2007; 28(4): 463-469 PubMed PMID: 17693978 Keywords: Adult, Case-Control Studies, Cyclooxygenase 2:metabolism, Depression:physiopathology, Fatigue:physiopathology, Fatigue Syndrome, Chronic:enzymology, Female, Humans, Inflammation:metabolism, Lymphocytes:metabolism, Male, Middle Aged, NF-kappa B:metabolism,. Citation: Chronic fatigue syndrome (CFS) is a medically unexplained disorder, characterized by profound fatigue, infectious, rheumatological and n.....
Maes M, Mihaylova I, Kubera M, Bosmans E. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett. 2007 Aug; 28(4): 463-469
Kubera M, Basta-Kaim A, Wróbel A, Maes M, Dudek D.
Journal Article 2004; 25(3): 207-210 PubMed PMID: 15349087 Keywords: Adult, Concanavalin A:pharmacology, Depression:immunology, Depressive Disorder:immunology, Female, Humans, Lymphocyte Activation:drug effects, Male, Middle Aged, Mitogens:pharmacology, Phytohemagglutinins:pharmacology, Reference Values, T-Lymphocytes:drug. CitationBACKGROUND: The biological basis of treatment resistance in depression still remains unclear. Some studies suggest that there exists a rel.....
Kubera M, Basta-Kaim A, Wróbel A, Maes M, Dudek D. Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: a preliminary study. Neuro Endocrinol Lett. 2004 Jun; 25(3): 207-210