Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E.
Journal Article 2010; 31(Suppl 2): 26-35 PubMed PMID: 21187821 Keywords: Animals, Antineoplastic Agents:metabolism, Biotransformation:drug effects, Cytochrome P-450 Enzyme System:physiology, DNA Adducts:drug effects, Ellipticines:metabolism, Kidney:metabolism, Liver:metabolism, Lung:metabolism, Male, Microsomes:drug effects, M. CitationOBJECTIVE: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be consider.....
Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E. Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney. Neuro Endocrinol Lett. 2010 Jan; 31(Suppl 2): 26-35
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 72-79 PubMed PMID: 20027148 Keywords: Absorption, Amino Acid Sequence, Animals, Apoproteins:chemistry, Butanones, Chromatography, Cytochromes b5:chemistry, Electrons, Electrophoresis, Polyacrylamide Gel, Heme:chemistry, Horses, Hydrogen-Ion Concentration, Mass Spectrometry, Molecular Sequence. CitationOBJECTIVES: Cytochrome b5 (cyt b5), a component of endoplasmic reticulum membrane, plays a role in modulation of activity of several cytoc.....
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M. Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 72-79
Martinkova E, Dontenwill M, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 60-66 PubMed PMID: 20027146 Keywords: Antineoplastic Agents:administration & dosage, Autoradiography, Blotting, Western, Cell Line, Tumor, Cell Proliferation:drug effects, Cell Survival:drug effects, Chromatography, High Pressure Liquid, Cytochrome P-450 Enzyme System:metabolism, DNA Adducts:. CitationOBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action with promising brain tumor specificity. .....
Martinkova E, Dontenwill M, Frei E, Stiborova M. Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 60-66
Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 52-59 PubMed PMID: 20027145 Keywords: Animals, Benz(a)Anthracenes:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Male, Microsomes, Liver:enzymology, Oxidati. CitationOBJECTIVES: 3-Aminobenzanthrone (3-ABA) is the main human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone (3-NBA). .....
Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M. Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 52-59
Svobodova M, Martinkova M, Dracinska H, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 46-51 PubMed PMID: 20027144 Keywords: Animals, Anisoles:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Microsomes, Liver:enzymology, Nitrophenols:metabolism. CitationOBJECTIVES: 2-Nitrophenol (2-NP) is the major detoxification metabolite of an important industrial pollutant and a potent carcinogen, 2-ni.....
Svobodova M, Martinkova M, Dracinska H, Frei E, Stiborova M. Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 46-51
Semanska M, Dracinsky M, Martinek V, Hudecek J, Hodek P, Frei E, Stiborova M.
Journal Article 2008; 29(5): 712-716 PubMed PMID: 18987613 Keywords: Carcinogens:chemistry, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Electrons, Horseradish Peroxidase:chemistry, Hydrogen Peroxide:chemistry, Magnetic Resonance Spectroscopy, Mass Spectrometry, Naphthols:chemistry, Oxidation-Reduction. CitationOBJECTIVES: The aim of the study was to examine oxidation of carcinogenic Sudan I by peroxidase and characterize the structure of its two .....
Semanska M, Dracinsky M, Martinek V, Hudecek J, Hodek P, Frei E, Stiborova M. A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase. Neuro Endocrinol Lett. 2008 Oct; 29(5): 712-716