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NEUROENDOCRINOLOGY
LETTERS
including
Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X
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NEL
Vol.24 Nos.3/4, Jun-Aug 2003
REVIEW ARTICLE
The
role of the estrogen in neuroprotection: Implications for neurodegenerative
diseases
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2003;
24:
141–147
pii: NEL243403R01
PMID: 14523347
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Related
PRESS RELEASE
Related Articles
in this issue:
1. Preface - Guest Editorial by Stefano
2. Stefano et al | 3.
Zhu et al | 4. Cho et
al - Review (below) |
REVIEW
ARTICLE
The
role of the estrogen in neuroprotection: Implications for
neurodegenerative diseases
John
J. Cho, Francesco A. Iannucci, Melissa Fraile, Joseph Franco,
Tracy N. Alesius & George B. Stefano
Neuroscience Research Institute, State University of New York
College at Old Westbury, Old Westbury, New York, USA;
Submitted:
July 22, 2003
Accepted: July 24, 2003
Key
words:
17-b-estradiol, estrogen cell
surface receptors, nitric oxide, estrogen receptors, microglia,
Alzheimer’s Disease, Parkinson’s Disease, free radicals, schizophrenia
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Abstract
OBJECTIVES:
In earlier studies, we demonstrate that 17-b
-estradiol and an estrogen cell surface receptor can be found
on various human cells, i.e., vascular endothelial, monocytes,
and granulocytes, where they are coupled to nitric oxide release.
We further demonstrated this phenomenon in the marine mussel
Mytilus edulis ganglionic tissues. In the present report we
sought to determine if estrogen can be found in M. edulis
reproductive tissues.
MATERIAL
& METHODS: We determined the presence of 17-b
-estradiol via high pressure liquid chromatography (HPLC)
and radioimmunoassay (RIA) in the animals gonads. This substance
was further identified via nanoelectro-spray ionization quadrupole
time of flight mass spectrometry (Q-TOF-MS).
RESULTS:
17-b -estradiol was identified
and quantified in Mytilus gonads. Interestingly, we also determined
that estradiol isoforms also were present in this tissue.
CONCLUSION:
These data demonstrate that 17-b-estradiol
and an estradiol isoform is present in M. edulis gonadal tissues,
suggesting that they have functions related to reproduction.
This further suggests that estrogen’s association with
reproductive activities has a long evolutionary history and
that this association began in invertebrates.
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__________________________________________________________
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
All rights reserved. No part may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means,
electronic, mechanical, photocopying, recording, or ortherwise,
without prior written permission from the Editor-in-Chief.
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